Interstate 65 (I-65) is a major north-south Interstate Highway in the United States that extends approximately 1,317 miles (2,118 kilometers). Starting from New Orleans, Louisiana, it travels through Mississippi, Alabama, Tennessee, Kentucky, and Indiana before ending in Chicago, Illinois. This key transportation route serves as a vital connection between the Gulf Coast, Midwest, and Mid-Atlantic regions of the country. The highway is part of the Dwight D. Eisenhower National System of Interstate Highways, which aims to provide safe, efficient travel across the nation. I-65 features numerous urban interchanges, service areas, rest stops, and scenic overlooks along its route, accommodating a high volume of traffic and offering amenities for travelers.